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The principal cytochrome P450 isoenzyme associated seems to be CYP2E1, with CYP1A2 and CYP3A4 as extra pathways. Approximately eighty five% of an oral dose appears in the urine inside 24 several hours of administration, most given that the glucuronide conjugate, with little amounts of other conjugates and unchanged drug (see OVERDOSAGE) for toxicit